KMID : 0352720220460030473
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Journal of Ginseng Research 2022 Volume.46 No. 3 p.473 ~ p.480
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Effects of red ginseng oil(KGC11o) on testosterone-propionate-induced benign prostatic hyperplasia
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Lee Jeong-Yoon
Kim So-Hyuk Kim Jong-Han Bae Bong-Seok Koo Gi-Bang So Seung-Ho Lee Jeong-Min Lee Yoo-Hyun
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Abstract
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Background: Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation of the prostate, which occurs frequently in middle-aged men. In this study, we report the effect of red ginseng oil (KGC11o) on BPH.
Methods: The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o 25, 50, 100, 200, and finasteride groups. KGC11o and finasteride were administered for 8 weeks. The BPH biomarkers, DHT, 5AR1, and 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, and TGF-¥â were determined in the serum and prostate tissue. The cell viability after KGC11o treatment was determined using BPH-1 cells, and, androgen receptor, Bax, Bcl-2, and TGF-¥â were confirmed by western blotting.
Results: In the in vivo study, administration of KGC11o reduced prostate weight by 18%, suppressed DHT (up to 22%) and 5AR2 (up to 12%) levels from administration of 100 mg/kg KGC11o (P < 0.05). PSA was significantly downregulated dose-dependently from at the concentration of 50 mg/kg KGC11o (P < 0.05). BPH-1 cell viability significantly reduced through the treatment with KGC11o. In vitro and vivo, AR, Bcl-2 TGF-¥â levels reduced significantly but Bax was increased (P < 0.05).
Conclusion: These results suggest that KGC11o may inhibit the development of BPH by significantly reducing the levels of BPH biomarkers via 5ARI, anti-androgenic effect, and anti-proliferation effect, serving as a potential functional food for treating BPH.
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KEYWORD
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Androgen receptor, 5alpha-reductase, BPH, Red ginseng oil, KGC11o
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